This case involves the care of a neonate born at a hospital in Montana. The neonate needed to undergo a great vessel switch after birth in order to correct a genetic defect. During the surgery, the surgeons noticed unusual bleeding. The physicians administered Novo7 to assist in minimizing the surgical time. The drug immediately caused a stroke of the cerebral artery, rendering the child severely disabled.
Depending on the nature of the genetic abnormality, the pharmacological effect of the Novo7 could be altered, or its dose could be incorrect for the patient’s metabolism, or the sensitivity to the Novo7 itself could be altered. There are other considerations as well, such as whether the stroke was caused by failure of the drug, excessive concentrations of the drug, or if the surgery itself was somehow responsible for the clot (if it was a clot). I specialize in complex cases where there are many interacting variables and pharmacology can help sort them out.
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